Institute of Genetics

Subacute necrotising encephalopathy (SNE) in the Yorkshire Terrier

ZNS-Läsionsmuster bei SNE erkrankten Yorkshire Terriern.
CNS lesion pattern in SNE-affected Yorkshire Terriers Baiker et al. (2009) Acta Neuropathol 118:697-709.

Subacute necrotising encephalopathy (SNE) in Yorkshire Terriers is a lethal necrotising brain disease affecting dogs of both sexes less than 1 year of age. Clinically, the disease is characterized by gait abnormalities, central visual deficits, and reduced mental state. Neuropathologically, SNE in Yorkshire Terriers is nearly identical to the Alaskan Husky form and very similar to human Leigh syndrome. We would like to investigate the genetic cause of SNE in order to develop a DNA test, which will allow the unequivocal diagnosis of carriers. For our research we ask breeders and owners of affected dogs to donate samples of the affected individuals and their relatives